Assay Detail
Functional
CHEMBL619509
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Cytotoxicity against human A549 non small cell lung cell lines
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of 3-alkyl- and 3-alkenyl-3-dephenyldocetaxels
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.11 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339531 | — | — | 1 | 9.57 |
| CHEMBL89997 | — | — | 1 | 9.35 |
| CHEMBL313351 | — | — | 1 | 9.27 |
| CHEMBL89290 | — | — | 1 | 9.15 |
| CHEMBL315858 | — | — | 1 | 9.01 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339531 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL89997 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL313351 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL89290 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL315858 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.6 | nM | 8.44 |