Assay Detail
Binding
CHEMBL619875
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase in human whole blood.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.77 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423835 | ZM-211965 | — | 1 | 6.40 |
| CHEMBL70191 | — | — | 1 | 6.30 |
| CHEMBL20905 | — | — | 1 | 6.22 |
| CHEMBL430614 | — | — | 1 | 5.32 |
| CHEMBL416735 | — | — | 1 | 5.20 |
| CHEMBL304320 | — | — | 1 | 5.16 |
| CHEMBL70580 | — | — | 1 | - |
| CHEMBL308453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423835 | ZM-211965 | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL70191 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL20905 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL430614 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL416735 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL304320 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL70580 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL308453 | — | IC50 | ~ | 40000.0 | nM | - |