Assay Detail
Functional
CHEMBL619878
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro 5-lipoxygenase inhibitory activity against calcium ionophore (A23187) induced LTB4 formation in human polymorphonuclear leukocytes.
38
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.38 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127109 | — | — | 1 | 6.70 |
| CHEMBL30110 | — | — | 1 | 6.00 |
| CHEMBL7660 | PHENIDONE | — | 1 | 5.89 |
| CHEMBL129798 | — | — | 1 | 5.80 |
| CHEMBL127110 | — | — | 1 | 5.77 |
| CHEMBL341363 | — | — | 1 | 5.75 |
| CHEMBL128663 | — | — | 1 | 5.70 |
| CHEMBL126290 | — | — | 1 | 5.68 |
| CHEMBL127719 | — | — | 1 | 5.66 |
| CHEMBL129701 | — | — | 1 | 5.58 |
| CHEMBL341291 | — | — | 1 | 5.58 |
| CHEMBL126672 | — | — | 1 | 5.57 |
| CHEMBL128138 | — | — | 1 | 5.52 |
| CHEMBL129260 | — | — | 1 | 5.51 |
| CHEMBL129799 | — | — | 1 | 5.46 |
| CHEMBL339537 | — | — | 1 | 5.44 |
| CHEMBL128308 | — | — | 1 | 5.42 |
| CHEMBL340784 | — | — | 1 | 5.34 |
| CHEMBL128429 | — | — | 1 | 5.34 |
| CHEMBL128758 | — | — | 1 | 5.32 |
| CHEMBL126183 | — | — | 1 | 5.32 |
| CHEMBL339239 | — | — | 1 | 5.28 |
| CHEMBL129506 | — | — | 1 | 5.28 |
| CHEMBL126135 | — | — | 1 | 5.26 |
| CHEMBL340341 | — | — | 2 | 5.24 |
| CHEMBL129818 | — | — | 1 | 5.24 |
| CHEMBL129428 | — | — | 1 | 5.22 |
| CHEMBL338785 | — | — | 1 | 5.15 |
| CHEMBL129441 | — | — | 1 | 5.10 |
| CHEMBL128657 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127109 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL30110 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL129798 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL127110 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL341363 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL128663 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL126290 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL127719 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL129701 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL341291 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL126672 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL128138 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL129260 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL129799 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL339537 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL128308 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL340784 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL128429 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL128758 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL126183 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL339239 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL129506 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL126135 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL340341 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL129818 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL129428 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL338785 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL129441 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL128657 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL127107 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL129344 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL340341 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL126191 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL340927 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL128869 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL129325 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL126949 | — | IC50 | > | 50000.0 | nM | - |