Assay Detail
Functional
CHEMBL619879
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro 5-lipoxygenase inhibitory activity against calcium ionophore (A23187) induced LTB4 formation in human whole blood
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.97 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7660 | PHENIDONE | — | 1 | 6.52 |
| CHEMBL30110 | — | — | 1 | 6.16 |
| CHEMBL340341 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7660 | PHENIDONE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL30110 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL340341 | — | IC50 | = | 5800.0 | nM | 5.24 |