Assay Detail
Binding
CHEMBL619899
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Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.39 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413707 | — | — | 1 | 9.30 |
| CHEMBL430706 | — | — | 1 | 9.17 |
| CHEMBL115262 | — | — | 1 | 9.15 |
| CHEMBL116292 | — | — | 1 | 9.10 |
| CHEMBL114345 | — | — | 1 | 9.08 |
| CHEMBL1256844 | — | — | 1 | 8.90 |
| CHEMBL323778 | — | — | 1 | 8.74 |
| CHEMBL330353 | — | — | 1 | 8.62 |
| CHEMBL331803 | — | — | 1 | 8.20 |
| CHEMBL111922 | — | — | 1 | 8.19 |
| CHEMBL112876 | — | — | 1 | 8.19 |
| CHEMBL113192 | — | — | 1 | 7.64 |
| CHEMBL112765 | — | — | 1 | 7.59 |
| CHEMBL112150 | — | — | 1 | 7.24 |
| CHEMBL111956 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413707 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL430706 | — | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL115262 | — | Ki | = | 0.7079 | nM | 9.15 |
| CHEMBL116292 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL114345 | — | Ki | = | 0.8318 | nM | 9.08 |
| CHEMBL1256844 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL323778 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL330353 | — | Ki | = | 2.399 | nM | 8.62 |
| CHEMBL331803 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL111922 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL112876 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL113192 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL112765 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL112150 | — | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL111956 | — | Ki | = | 165.96 | nM | 6.78 |