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Assay Detail

CHEMBL620107

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
The compound was tested in vitro for anticancer activity against 9L cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type 9L
Confidence 1 — Organism
Curated By Intermediate

Target

9L (CHEMBL613105)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
Shi J, McAtee JJ, Schlueter Wirtz S, Tharnish P, Juodawlkis A, Liotta DC, Schinazi RF.
J Med Chem (1999) 42 : 859 -867
PubMed 10072683 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.62 5.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2368322 1 5.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2368322 IC50 = 2400.0 nM 5.62