Assay Detail
Functional
CHEMBL620121
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Antiproliferative activity in vitro against A549 (human non-small lung carcinoma) cell line.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.19 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285340 | — | — | 1 | 7.00 |
| CHEMBL283420 | — | — | 1 | 6.70 |
| CHEMBL491263 | — | — | 1 | 6.70 |
| CHEMBL1202480 | — | — | 1 | 6.52 |
| CHEMBL283904 | — | — | 1 | 6.52 |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 6.52 |
| CHEMBL280788 | — | — | 1 | 6.52 |
| CHEMBL26584 | — | — | 1 | 6.30 |
| CHEMBL25921 | — | — | 1 | 5.70 |
| CHEMBL281423 | — | — | 1 | 5.51 |
| CHEMBL283812 | — | — | 1 | 5.48 |
| CHEMBL284064 | — | — | 1 | 4.78 |
| CHEMBL28100 | — | — | 1 | - |
| CHEMBL27761 | — | — | 1 | - |
| CHEMBL283655 | — | — | 1 | - |
| CHEMBL27781 | — | — | 1 | - |
| CHEMBL27644 | — | — | 1 | - |
| CHEMBL28587 | — | — | 1 | - |
| CHEMBL27509 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285340 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL283420 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL491263 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1202480 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL283904 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL280788 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL26584 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL25921 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL281423 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL283812 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL284064 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL28100 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27761 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL283655 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27781 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27644 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL28587 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27509 | — | IC50 | > | 10000.0 | nM | - |