Assay Detail
Functional
CHEMBL620136
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Inhibitory concentration required to reduce A549 tumor cell growth by 50% in MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.83 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.80 |
| CHEMBL99456 | — | — | 1 | 6.52 |
| CHEMBL95313 | — | — | 1 | 6.00 |
| CHEMBL99216 | — | — | 1 | 5.30 |
| CHEMBL95273 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL99456 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL95313 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL99216 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL95273 | — | IC50 | = | 29000.0 | nM | 4.54 |