Assay Detail
Functional
CHEMBL620168
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In vitro cytotoxicity against human tumor cell line A549
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.39 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109188 | — | — | 1 | 6.92 |
| CHEMBL441645 | — | — | 1 | 6.12 |
| CHEMBL109181 | — | — | 1 | 5.85 |
| CHEMBL107773 | — | — | 1 | 5.62 |
| CHEMBL109103 | — | — | 1 | 5.54 |
| CHEMBL111658 | — | — | 1 | 5.25 |
| CHEMBL109521 | — | — | 1 | 5.15 |
| CHEMBL109029 | — | — | 1 | 5.08 |
| CHEMBL322998 | — | — | 1 | 5.00 |
| CHEMBL420670 | — | — | 1 | 4.70 |
| CHEMBL108027 | — | — | 1 | 4.03 |
| CHEMBL108508 | — | — | 1 | - |
| CHEMBL432606 | — | — | 1 | - |
| CHEMBL322309 | — | — | 1 | - |
| CHEMBL321011 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL419007 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109188 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL441645 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL109181 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL107773 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL109103 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL111658 | — | IC50 | = | 5590.0 | nM | 5.25 |
| CHEMBL109521 | — | IC50 | = | 7020.0 | nM | 5.15 |
| CHEMBL109029 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL322998 | — | IC50 | = | 9960.0 | nM | 5.00 |
| CHEMBL420670 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL108027 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL108508 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL432606 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL322309 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL321011 | — | IC50 | = | 14000000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 330000.0 | nM | - |
| CHEMBL419007 | — | IC50 | = | 500000.0 | nM | - |