Assay Detail
Functional
CHEMBL620271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for antiproliferative activity against human A549 cancer cell lines using MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.05 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.10 |
| CHEMBL152543 | — | — | 1 | 6.46 |
| CHEMBL152133 | — | — | 1 | 6.32 |
| CHEMBL314389 | OXAMFLATIN | — | 1 | 6.08 |
| CHEMBL152538 | — | — | 1 | 5.78 |
| CHEMBL347068 | — | — | 1 | 5.65 |
| CHEMBL346525 | — | — | 1 | 5.54 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL152543 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL152133 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL314389 | OXAMFLATIN | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL152538 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL347068 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL346525 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 3580.0 | nM | 5.45 |