Assay Detail
Functional
CHEMBL620422
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Cytotoxicity against A549 tumor cell line determined by WST-1 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Topoisomerase I-mediated antiproliferative activity of enantiomerically pure fluorinated homocamptothecins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.85 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419083 | — | — | 1 | 8.72 |
| CHEMBL72974 | — | — | 1 | 8.54 |
| CHEMBL306280 | DIFLOMOTECAN | 2.0 | 1 | 8.47 |
| CHEMBL306721 | — | — | 1 | 7.77 |
| CHEMBL306796 | — | — | 1 | 7.66 |
| CHEMBL74190 | HOMOCAMPTOTHECIN | — | 1 | 7.58 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.17 |
| CHEMBL74863 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419083 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL72974 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL306280 | DIFLOMOTECAN | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL306721 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL306796 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL74190 | HOMOCAMPTOTHECIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL74863 | — | IC50 | = | 130.0 | nM | 6.89 |