Assay Detail
Functional
CHEMBL620427
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In vitro antitumor activity against A549 human non-small lung carcinoma cells containing 10% fetal bovine serum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Serum |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.56 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18155 | — | — | 1 | 8.89 |
| CHEMBL44919 | — | — | 1 | 8.28 |
| CHEMBL42819 | — | — | 1 | 7.66 |
| CHEMBL43150 | — | — | 1 | 7.64 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.64 |
| CHEMBL42142 | — | — | 1 | 7.35 |
| CHEMBL42109 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18155 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL44919 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL42819 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL43150 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL42142 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL42109 | — | IC50 | = | 3300.0 | nM | 5.48 |