Assay Detail
Functional
CHEMBL620430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro concentration required to inhibit the TNF-alpha-induced RANTES production in A549 human lung epithelium cell line
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.01 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL534692 | — | — | 1 | 6.10 |
| CHEMBL558038 | — | — | 1 | 5.30 |
| CHEMBL426403 | — | — | 1 | 5.22 |
| CHEMBL173484 | — | — | 1 | 5.16 |
| CHEMBL173050 | — | — | 1 | 5.10 |
| CHEMBL535135 | — | — | 1 | 5.10 |
| CHEMBL535358 | — | — | 1 | 5.00 |
| CHEMBL174140 | — | — | 1 | 4.82 |
| CHEMBL262056 | — | — | 1 | 4.82 |
| CHEMBL170563 | — | — | 1 | 4.82 |
| CHEMBL434691 | — | — | 1 | 4.70 |
| CHEMBL534462 | — | — | 1 | 4.52 |
| CHEMBL352549 | — | — | 1 | 4.46 |
| CHEMBL170406 | — | — | 1 | - |
| CHEMBL535359 | — | — | 1 | - |
| CHEMBL174430 | — | — | 1 | - |
| CHEMBL440200 | — | — | 1 | - |
| CHEMBL171587 | — | — | 1 | - |
| CHEMBL354947 | — | — | 1 | - |
| CHEMBL170355 | — | — | 1 | - |
| CHEMBL173111 | — | — | 1 | - |
| CHEMBL170189 | — | — | 1 | - |
| CHEMBL352957 | — | — | 1 | - |
| CHEMBL424766 | — | — | 1 | - |
| CHEMBL174201 | — | — | 1 | - |
| CHEMBL424000 | — | — | 1 | - |
| CHEMBL366730 | — | — | 1 | - |
| CHEMBL444345 | — | — | 1 | - |
| CHEMBL170024 | — | — | 1 | - |
| CHEMBL171291 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL534692 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL558038 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL426403 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL173484 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL173050 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL535135 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL535358 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL174140 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL262056 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL170563 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL434691 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL534462 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL352549 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL173747 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL171680 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL170463 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL366530 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL170406 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL535359 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL174430 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL440200 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL171587 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL354947 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL170355 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL173111 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL170189 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL352957 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL424766 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL174201 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL424000 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL366730 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL444345 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL170024 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL171291 | — | IC50 | > | 50000.0 | nM | - |