Assay Detail
Functional
CHEMBL620437
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Inhibition of human ovarian carcinoma (A90) FGF-R overexpressing cell proliferation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ovarian cancer cell line |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.15 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339856 | — | — | 1 | 6.04 |
| CHEMBL134354 | — | — | 1 | 5.92 |
| CHEMBL422625 | — | — | 1 | 5.03 |
| CHEMBL135074 | — | — | 1 | 4.96 |
| CHEMBL135889 | — | — | 1 | 4.92 |
| CHEMBL299763 | — | — | 1 | 4.82 |
| CHEMBL134334 | — | — | 1 | 4.77 |
| CHEMBL133604 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339856 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL134354 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL422625 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL135074 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL135889 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL299763 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL134334 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL133604 | — | IC50 | = | 17000.0 | nM | 4.77 |