Assay Detail
Binding
CHEMBL620619
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Binding affinity against 5-hydroxytryptamine 2C receptor using [125I]DOI radioligand.
38
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 7.16 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76494 | — | — | 1 | 8.37 |
| CHEMBL77234 | — | — | 1 | 8.33 |
| CHEMBL312258 | — | — | 1 | 8.32 |
| CHEMBL310620 | — | — | 1 | 8.21 |
| CHEMBL312742 | — | — | 1 | 8.17 |
| CHEMBL310473 | — | — | 1 | 7.92 |
| CHEMBL312179 | — | — | 1 | 7.89 |
| CHEMBL77701 | — | — | 2 | 7.85 |
| CHEMBL6557 | PNU-22394 | — | 1 | 7.72 |
| CHEMBL311726 | — | — | 1 | 7.64 |
| CHEMBL76645 | — | — | 2 | 7.52 |
| CHEMBL312762 | — | — | 3 | 7.50 |
| CHEMBL308958 | — | — | 1 | 7.42 |
| CHEMBL310497 | — | — | 1 | 7.37 |
| CHEMBL310090 | — | — | 1 | 7.27 |
| CHEMBL310540 | — | — | 1 | 7.24 |
| CHEMBL80603 | — | — | 1 | 7.19 |
| CHEMBL312222 | — | — | 1 | 7.13 |
| CHEMBL78164 | — | — | 1 | 7.07 |
| CHEMBL76099 | — | — | 3 | 6.99 |
| CHEMBL76153 | — | — | 1 | 6.95 |
| CHEMBL79153 | — | — | 1 | 6.87 |
| CHEMBL311614 | — | — | 1 | 6.80 |
| CHEMBL310844 | — | — | 1 | 6.65 |
| CHEMBL77418 | — | — | 1 | 6.58 |
| CHEMBL80706 | — | — | 1 | 6.51 |
| CHEMBL309570 | — | — | 1 | 6.41 |
| CHEMBL75738 | — | — | 1 | 6.33 |
| CHEMBL306540 | — | — | 1 | 6.14 |
| CHEMBL310984 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76494 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL77234 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL312258 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL310620 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL312742 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL310473 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL312179 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL77701 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL6557 | PNU-22394 | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL311726 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL76645 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL312762 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL308958 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL76645 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL310497 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL310090 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL312762 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL310540 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL77701 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL80603 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL312222 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL78164 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL76099 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL76099 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL76153 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL79153 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL311614 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL312762 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL76099 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL310844 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL77418 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL80706 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL309570 | — | Ki | = | 386.0 | nM | 6.41 |
| CHEMBL75738 | — | Ki | = | 472.0 | nM | 6.33 |
| CHEMBL306540 | — | Ki | = | 721.0 | nM | 6.14 |
| CHEMBL310984 | — | Ki | = | 793.0 | nM | 6.10 |
| CHEMBL305655 | — | Ki | = | 932.0 | nM | 6.03 |
| CHEMBL310797 | — | Ki | = | 4815.0 | nM | 5.32 |