Assay Detail
Binding
CHEMBL620664
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Binding affinity towards 5-hydroxytryptamine 2C receptor using [3H]mesulergine as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.46 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 1 | 7.96 |
| CHEMBL307956 | — | — | 1 | 7.62 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL307956 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 160.0 | nM | 6.80 |