Assay Detail
Binding
CHEMBL620705
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Binding affinity towards cloned human 5-hydroxytryptamine 4E receptor expressed in C6 glial cells using [3H]GR-113808 as radioligand
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | C6 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and characterization of the first fluorescent antagonists for human 5-HT4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.25 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286136 | — | — | 1 | 9.00 |
| CHEMBL328918 | — | — | 1 | 8.15 |
| CHEMBL89225 | — | — | 1 | 8.12 |
| CHEMBL315590 | — | — | 1 | 7.62 |
| CHEMBL86777 | — | — | 1 | 7.51 |
| CHEMBL327999 | — | — | 1 | 7.50 |
| CHEMBL88355 | — | — | 1 | 7.23 |
| CHEMBL85125 | — | — | 1 | 7.19 |
| CHEMBL90559 | — | — | 1 | 7.11 |
| CHEMBL315526 | — | — | 1 | 7.02 |
| CHEMBL86985 | — | — | 1 | 6.94 |
| CHEMBL86624 | — | — | 1 | 6.75 |
| CHEMBL156206 | — | — | 1 | 6.74 |
| CHEMBL87063 | — | — | 1 | 6.74 |
| CHEMBL433149 | — | — | 1 | 6.58 |
| CHEMBL312940 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286136 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL328918 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL89225 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL315590 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL86777 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL327999 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL88355 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL85125 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL90559 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL315526 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL86985 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL86624 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL156206 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL87063 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL433149 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL312940 | — | Ki | = | 1720.0 | nM | 5.76 |