Assay Detail
Functional
CHEMBL620719
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated in vivo for the antagonistic activity towards 5-hydroxytryptamine 3 receptor
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 3A (CHEMBL2411) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New aza(nor)adamantanes are agonists at the newly identified serotonin 5-HT4 receptor and antagonists at the 5-HT3 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.94 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28992 | — | — | 1 | 9.64 |
| CHEMBL2448165 | — | — | 1 | 8.92 |
| CHEMBL2448137 | — | — | 1 | 8.41 |
| CHEMBL296522 | RENZAPRIDE | 3.0 | 1 | 8.25 |
| CHEMBL295155 | — | — | 2 | 8.05 |
| CHEMBL1729 | CISAPRIDE | 4.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28992 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL2448165 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2448137 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL296522 | RENZAPRIDE | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL295155 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL295155 | — | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL1729 | CISAPRIDE | Ki | = | 1500.0 | nM | 5.82 |