Assay Detail
Binding
CHEMBL620729
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Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.91 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94117 | — | — | 1 | 9.54 |
| CHEMBL442382 | — | — | 1 | 9.51 |
| CHEMBL330293 | — | — | 1 | 9.06 |
| CHEMBL92643 | — | — | 1 | 9.02 |
| CHEMBL289060 | — | — | 1 | 9.00 |
| CHEMBL91158 | — | — | 1 | 8.82 |
| CHEMBL329322 | — | — | 1 | 8.70 |
| CHEMBL329154 | — | — | 1 | 8.70 |
| CHEMBL40260 | — | — | 1 | 8.48 |
| CHEMBL329793 | — | — | 1 | 8.43 |
| CHEMBL316108 | — | — | 1 | 8.31 |
| CHEMBL330485 | — | — | 1 | 8.15 |
| CHEMBL93963 | — | — | 1 | 8.06 |
| CHEMBL327431 | — | — | 1 | 7.57 |
| CHEMBL315664 | — | — | 1 | 7.54 |
| CHEMBL328321 | — | — | 1 | 7.47 |
| CHEMBL91429 | — | — | 1 | 7.21 |
| CHEMBL93729 | — | — | 1 | 7.02 |
| CHEMBL93179 | — | — | 1 | 6.96 |
| CHEMBL93339 | — | — | 1 | 6.57 |
| CHEMBL1947052 | — | — | 1 | 6.48 |
| CHEMBL329658 | — | — | 1 | 6.41 |
| CHEMBL314085 | — | — | 1 | 6.40 |
| CHEMBL316107 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94117 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL442382 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL330293 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL92643 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL289060 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL91158 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL329322 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL329154 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL40260 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL329793 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL316108 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL330485 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL93963 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL327431 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL315664 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL328321 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL91429 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL93729 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL93179 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL93339 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL1947052 | — | Ki | = | 329.0 | nM | 6.48 |
| CHEMBL329658 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL314085 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL316107 | — | Ki | = | 430.0 | nM | 6.37 |