Assay Detail
Binding
CHEMBL620782
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Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]LSD as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.25 | 9.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24474 | — | — | 1 | 9.94 |
| CHEMBL23038 | — | — | 1 | 9.00 |
| CHEMBL23575 | — | — | 1 | 8.64 |
| CHEMBL23965 | — | — | 1 | 7.37 |
| CHEMBL415464 | — | — | 1 | 7.27 |
| CHEMBL542806 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24474 | — | Ki | = | 0.1148 | nM | 9.94 |
| CHEMBL23038 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL23575 | — | Ki | = | 2.291 | nM | 8.64 |
| CHEMBL23965 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL415464 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL542806 | — | Ki | = | 54.95 | nM | 7.26 |