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Assay Detail

CHEMBL620784

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against human 5-hydroxytryptamine 6 receptor
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 6 (CHEMBL3371) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).
Bromidge SM, Clarke SE, Gager T, Griffith K, Jeffrey P, Jennings AJ, Joiner GF, King FD, Lovell PJ, Moss SF, Newman H, Riley G, Rogers D, Routledge C, Serafinowska H, Smith DR.
Bioorg Med Chem Lett (2001) 11 : 55 -58
PubMed 11140733 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 40 8.65 9.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414628 — — 1 9.50
CHEMBL356021 — — 1 9.50
CHEMBL157454 — — 1 9.30
CHEMBL346338 — — 1 9.30
CHEMBL155717 — — 1 9.30
CHEMBL345110 — — 1 9.20
CHEMBL151998 — — 1 9.10
CHEMBL154089 — — 1 9.10
CHEMBL151295 — — 1 9.10
CHEMBL154675 — — 1 9.00
CHEMBL154274 — — 1 9.00
CHEMBL157173 — — 1 8.90
CHEMBL154367 — — 1 8.90
CHEMBL348870 — — 1 8.90
CHEMBL154273 — — 1 8.90
CHEMBL155106 — — 1 8.80
CHEMBL157338 — — 1 8.80
CHEMBL157103 — — 1 8.70
CHEMBL157910 — — 1 8.70
CHEMBL346990 — — 1 8.70
CHEMBL156130 — — 1 8.70
CHEMBL348364 — — 1 8.60
CHEMBL154720 — — 1 8.60
CHEMBL154641 — — 1 8.60
CHEMBL154525 — — 1 8.60
CHEMBL152806 — — 1 8.50
CHEMBL154842 — — 1 8.50
CHEMBL154534 — — 1 8.50
CHEMBL329383 — — 1 8.50
CHEMBL350022 — — 1 8.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414628 — Ki = 0.3162 nM 9.50
CHEMBL356021 — Ki = 0.3162 nM 9.50
CHEMBL157454 — Ki = 0.5012 nM 9.30
CHEMBL346338 — Ki = 0.5012 nM 9.30
CHEMBL155717 — Ki = 0.5012 nM 9.30
CHEMBL345110 — Ki = 0.631 nM 9.20
CHEMBL151998 — Ki = 0.7943 nM 9.10
CHEMBL154089 — Ki = 0.7943 nM 9.10
CHEMBL151295 — Ki = 0.7943 nM 9.10
CHEMBL154675 — Ki = 1.0 nM 9.00
CHEMBL154274 — Ki = 1.0 nM 9.00
CHEMBL157173 — Ki = 1.259 nM 8.90
CHEMBL154367 — Ki = 1.259 nM 8.90
CHEMBL348870 — Ki = 1.259 nM 8.90
CHEMBL154273 — Ki = 1.259 nM 8.90
CHEMBL155106 — Ki = 1.585 nM 8.80
CHEMBL157338 — Ki = 1.585 nM 8.80
CHEMBL156130 — Ki = 1.995 nM 8.70
CHEMBL346990 — Ki = 1.995 nM 8.70
CHEMBL157103 — Ki = 1.995 nM 8.70
CHEMBL157910 — Ki = 1.995 nM 8.70
CHEMBL348364 — Ki = 2.512 nM 8.60
CHEMBL154720 — Ki = 2.512 nM 8.60
CHEMBL154641 — Ki = 2.512 nM 8.60
CHEMBL154525 — Ki = 2.512 nM 8.60
CHEMBL152806 — Ki = 3.162 nM 8.50
CHEMBL154842 — Ki = 3.162 nM 8.50
CHEMBL154534 — Ki = 3.162 nM 8.50
CHEMBL329383 — Ki = 3.162 nM 8.50
CHEMBL350022 — Ki = 3.981 nM 8.40
CHEMBL153918 — Ki = 3.981 nM 8.40
CHEMBL157285 — Ki = 3.981 nM 8.40
CHEMBL156610 — Ki = 3.981 nM 8.40
CHEMBL155234 — Ki = 3.981 nM 8.40
CHEMBL157175 — Ki = 5.012 nM 8.30
CHEMBL350026 — Ki = 7.943 nM 8.10
CHEMBL154186 — Ki = 19.95 nM 7.70
CHEMBL346227 — Ki = 25.12 nM 7.60
CHEMBL158094 — Ki = 31.62 nM 7.50
CHEMBL347335 — Ki = 158.49 nM 6.80