Assay Detail
Binding
CHEMBL620785
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Binding affinity against human cloned 5-hydroxytryptamine 6 receptor in HeLa cells using [3H]LSD
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.24 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29846 | — | — | 1 | 9.20 |
| CHEMBL62368 | — | — | 1 | 9.10 |
| CHEMBL62538 | — | — | 1 | 9.10 |
| CHEMBL291618 | — | — | 1 | 9.00 |
| CHEMBL61318 | — | — | 1 | 8.90 |
| CHEMBL542139 | — | — | 1 | 8.90 |
| CHEMBL304039 | — | — | 1 | 8.70 |
| CHEMBL60264 | — | — | 1 | 8.60 |
| CHEMBL409160 | — | — | 1 | 8.50 |
| CHEMBL292759 | — | — | 1 | 8.30 |
| CHEMBL60669 | — | — | 1 | 8.00 |
| CHEMBL46071 | — | — | 1 | 7.90 |
| CHEMBL433461 | — | — | 1 | 7.30 |
| CHEMBL62594 | — | — | 1 | 7.20 |
| CHEMBL302845 | — | — | 1 | 7.10 |
| CHEMBL64715 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29846 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL62368 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL62538 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL291618 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL61318 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL542139 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL304039 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL60264 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL409160 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL292759 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL60669 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL46071 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL433461 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL62594 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL302845 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL64715 | — | Ki | = | 794.33 | nM | 6.10 |