Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL620800

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human 5-hydroxytryptamine 6 receptor
52
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 6 (CHEMBL3371)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Glennon RA.
J Med Chem (2003) 46 : 2795 -2812
PubMed 12825922 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 52 7.90 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96745 1 9.52
CHEMBL29846 1 9.22
CHEMBL46187 1 9.15
CHEMBL94093 1 9.10
CHEMBL29433 1 9.10
CHEMBL443796 1 9.05
CHEMBL431298 1 9.00
CHEMBL329329 1 8.89
CHEMBL95136 1 8.85
CHEMBL92093 1 8.82
CHEMBL92139 1 8.82
CHEMBL94569 1 8.70
CHEMBL76237 2 8.68
CHEMBL908 CHLORPROTHIXENE 4.0 1 8.52
CHEMBL329383 1 8.52
CHEMBL94422 1 8.51
CHEMBL71 CHLORPROMAZINE 4.0 1 8.40
CHEMBL42 CLOZAPINE 4.0 1 8.40
CHEMBL93868 1 8.39
CHEMBL98511 1 8.30
CHEMBL72554 1 8.30
CHEMBL292759 1 8.30
CHEMBL98237 1 8.19
CHEMBL329739 1 8.16
CHEMBL319956 1 8.14
CHEMBL98404 1 8.10
CHEMBL328816 1 7.92
CHEMBL831 LOXAPINE 4.0 1 7.82
CHEMBL267615 1 7.80
CHEMBL7257 MEBUFOTENIN 2.0 1 7.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96745 Ki = 0.3 nM 9.52
CHEMBL29846 Ki = 0.6 nM 9.22
CHEMBL46187 Ki = 0.7 nM 9.15
CHEMBL94093 Ki = 0.8 nM 9.10
CHEMBL29433 Ki = 0.8 nM 9.10
CHEMBL443796 Ki = 0.9 nM 9.05
CHEMBL431298 Ki = 1.0 nM 9.00
CHEMBL329329 Ki = 1.3 nM 8.89
CHEMBL95136 Ki = 1.4 nM 8.85
CHEMBL92093 Ki = 1.5 nM 8.82
CHEMBL92139 Ki = 1.5 nM 8.82
CHEMBL94569 Ki = 2.0 nM 8.70
CHEMBL76237 Ki = 2.1 nM 8.68
CHEMBL76237 Ki = 2.3 nM 8.64
CHEMBL908 CHLORPROTHIXENE Ki = 3.0 nM 8.52
CHEMBL329383 Ki = 3.0 nM 8.52
CHEMBL94422 Ki = 3.1 nM 8.51
CHEMBL71 CHLORPROMAZINE Ki = 4.0 nM 8.40
CHEMBL42 CLOZAPINE Ki = 4.0 nM 8.40
CHEMBL93868 Ki = 4.1 nM 8.39
CHEMBL98511 Ki = 5.0 nM 8.30
CHEMBL72554 Ki = 5.0 nM 8.30
CHEMBL292759 Ki = 5.0 nM 8.30
CHEMBL98237 Ki = 6.5 nM 8.19
CHEMBL329739 Ki = 6.9 nM 8.16
CHEMBL319956 Ki = 7.2 nM 8.14
CHEMBL98404 Ki = 7.9 nM 8.10
CHEMBL328816 Ki = 12.0 nM 7.92
CHEMBL831 LOXAPINE Ki = 15.0 nM 7.82
CHEMBL267615 Ki = 16.0 nM 7.80
CHEMBL7257 MEBUFOTENIN Ki = 16.0 nM 7.80
CHEMBL316881 Ki = 18.0 nM 7.75
CHEMBL317535 Ki = 20.0 nM 7.70
CHEMBL7318 Ki = 20.0 nM 7.70
CHEMBL96317 Ki = 20.0 nM 7.70
CHEMBL94969 Ki = 33.0 nM 7.48
CHEMBL329075 Ki = 50.0 nM 7.30
CHEMBL97492 Ki = 55.0 nM 7.26
CHEMBL7143 Ki = 60.0 nM 7.22
CHEMBL1423 PIMOZIDE Ki = 71.0 nM 7.15
CHEMBL268800 Ki = 80.0 nM 7.10
CHEMBL319322 Ki = 130.0 nM 6.89
CHEMBL329046 Ki = 136.0 nM 6.87
CHEMBL32029 Ki = 154.0 nM 6.81
CHEMBL7228 Ki = 168.0 nM 6.78
CHEMBL316855 Ki = 200.0 nM 6.70
CHEMBL97819 Ki = 1000.0 nM 6.00
CHEMBL267930 SPIPERONE Ki = 1595.0 nM 5.80
CHEMBL281408 Ki = 8000.0 nM 5.10
CHEMBL97017 Ki = 19600.0 nM 4.71