Assay Detail
Binding
CHEMBL620825
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Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.46 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL161765 | — | — | 1 | 9.22 |
| CHEMBL158402 | — | — | 1 | 9.15 |
| CHEMBL158973 | — | — | 1 | 8.89 |
| CHEMBL158285 | — | — | 1 | 8.39 |
| CHEMBL159143 | — | — | 1 | 8.14 |
| CHEMBL345803 | — | — | 1 | 7.92 |
| CHEMBL161203 | — | — | 1 | 7.66 |
| CHEMBL350166 | — | — | 1 | 7.57 |
| CHEMBL161846 | — | — | 1 | 7.08 |
| CHEMBL162071 | — | — | 1 | 7.00 |
| CHEMBL160903 | — | — | 1 | 6.77 |
| CHEMBL159223 | — | — | 1 | 5.92 |
| CHEMBL434477 | — | — | 1 | 5.50 |
| CHEMBL161031 | — | — | 1 | 5.17 |
| CHEMBL158287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL161765 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL158402 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL158973 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL158285 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL159143 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL345803 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL161203 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL350166 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL161846 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL162071 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL160903 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL159223 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL434477 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL161031 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL158287 | — | Ki | > | 4000.0 | nM | - |