Assay Detail
Functional
CHEMBL620871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for inhibition of the formation and release of 5-lipoxygenase in isolated guinea pig ileum
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.80 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290579 | — | — | 1 | 7.60 |
| CHEMBL36043 | — | — | 1 | 7.23 |
| CHEMBL285731 | — | — | 1 | 7.20 |
| CHEMBL290417 | — | — | 1 | 7.15 |
| CHEMBL38172 | — | — | 1 | 7.05 |
| CHEMBL285453 | — | — | 1 | 6.89 |
| CHEMBL35004 | — | — | 1 | 6.77 |
| CHEMBL35990 | — | — | 1 | 6.66 |
| CHEMBL277815 | — | — | 1 | 6.54 |
| CHEMBL36936 | — | — | 1 | 6.28 |
| CHEMBL8562 | — | — | 1 | 6.16 |
| CHEMBL274642 | BW-755C | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290579 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL36043 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL285731 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL290417 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL38172 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL285453 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL35004 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL35990 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL277815 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL36936 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL8562 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL274642 | BW-755C | IC50 | = | 750.0 | nM | 6.12 |