Assay Detail
Binding
CHEMBL620874
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Compound was evaluated for in vitro inhibition of recombinant human 5-lipoxygenase (5-LO)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.88 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278293 | — | — | 1 | 7.70 |
| CHEMBL22789 | — | — | 1 | 7.57 |
| CHEMBL22751 | — | — | 1 | 7.44 |
| CHEMBL23007 | — | — | 1 | 6.99 |
| CHEMBL280348 | — | — | 1 | 6.91 |
| CHEMBL22736 | — | — | 1 | 5.84 |
| CHEMBL417464 | — | — | 1 | 5.71 |
| CHEMBL22578 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278293 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL22789 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL22751 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL23007 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL280348 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL22736 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL417464 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL22578 | — | IC50 | > | 3000.0 | nM | - |