Assay Detail
Functional
CHEMBL623376
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Inhibition of the growth against human non-small-lung carcinoma (A549) cell line after 72 hr exposure
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of nonaromatic taxoids: effects of alkyl and alkenyl ester groups on cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.29 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339531 | — | — | 1 | 9.52 |
| CHEMBL95734 | — | — | 1 | 9.05 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.00 |
| CHEMBL318368 | — | — | 1 | 8.89 |
| CHEMBL318914 | — | — | 1 | 8.54 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.44 |
| CHEMBL95487 | — | — | 1 | 8.24 |
| CHEMBL321365 | — | — | 1 | 8.11 |
| CHEMBL319735 | — | — | 1 | 7.92 |
| CHEMBL93429 | — | — | 1 | 7.85 |
| CHEMBL317148 | — | — | 1 | 7.52 |
| CHEMBL318400 | — | — | 1 | 7.33 |
| CHEMBL98348 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339531 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL95734 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL318368 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL318914 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL95487 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL321365 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL319735 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL93429 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL317148 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL318400 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL98348 | — | IC50 | = | 49.0 | nM | 7.31 |