Assay Detail
Functional
CHEMBL623386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against A549 cancer cell line.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.64 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146516 | — | — | 1 | 8.77 |
| CHEMBL343913 | — | — | 1 | 8.60 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.51 |
| CHEMBL146785 | — | — | 1 | 8.32 |
| CHEMBL149293 | — | — | 1 | 8.32 |
| CHEMBL147372 | — | — | 1 | 8.32 |
| CHEMBL144014 | — | — | 1 | 8.15 |
| CHEMBL148281 | — | — | 1 | 8.09 |
| CHEMBL148344 | — | — | 1 | 8.00 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 8.00 |
| CHEMBL146037 | — | — | 1 | 7.92 |
| CHEMBL356785 | — | — | 1 | 7.85 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL344310 | — | — | 1 | 7.66 |
| CHEMBL439812 | — | — | 1 | 7.57 |
| CHEMBL149184 | — | — | 1 | 7.51 |
| CHEMBL422137 | — | — | 1 | 7.51 |
| CHEMBL356797 | — | — | 1 | 7.51 |
| CHEMBL345020 | — | — | 1 | 7.47 |
| CHEMBL439632 | — | — | 1 | 7.40 |
| CHEMBL146559 | — | — | 1 | 7.22 |
| CHEMBL147576 | — | — | 1 | 7.21 |
| CHEMBL148229 | — | — | 1 | 7.21 |
| CHEMBL343852 | — | — | 1 | 7.11 |
| CHEMBL358993 | — | — | 1 | 7.09 |
| CHEMBL147428 | — | — | 1 | 6.92 |
| CHEMBL422843 | — | — | 1 | 6.09 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146516 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL343913 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL146785 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL149293 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL147372 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL144014 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL148281 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL148344 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL146037 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL356785 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL344310 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL439812 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL149184 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL422137 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL356797 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL345020 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL439632 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL146559 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL147576 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL148229 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL343852 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL358993 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL147428 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL422843 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 1100.0 | nM | 5.96 |