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Assay Detail

CHEMBL623739

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Functional
In vitro inhibitory concentration against proliferation of A459 cell line.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Expert

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src.
Plé PA, Green TP, Hennequin LF, Curwen J, Fennell M, Allen J, Lambert-Van Der Brempt C, Costello G.
J Med Chem (2004) 47 : 871 -887
PubMed 14761189 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.46 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL169186 1 6.89
CHEMBL173799 1 6.85
CHEMBL369360 1 6.75
CHEMBL171125 1 6.68
CHEMBL354145 1 6.64
CHEMBL352977 1 6.64
CHEMBL169643 1 6.58
CHEMBL170984 1 6.58
CHEMBL172450 1 6.51
CHEMBL167890 1 6.35
CHEMBL352992 1 6.32
CHEMBL422564 1 6.17
CHEMBL353070 1 6.01
CHEMBL169797 1 5.98
CHEMBL352877 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL169186 IC50 = 130.0 nM 6.89
CHEMBL173799 IC50 = 140.0 nM 6.85
CHEMBL369360 IC50 = 180.0 nM 6.75
CHEMBL171125 IC50 = 210.0 nM 6.68
CHEMBL354145 IC50 = 230.0 nM 6.64
CHEMBL352977 IC50 = 230.0 nM 6.64
CHEMBL169643 IC50 = 260.0 nM 6.58
CHEMBL170984 IC50 = 260.0 nM 6.58
CHEMBL172450 IC50 = 310.0 nM 6.51
CHEMBL167890 IC50 = 450.0 nM 6.35
CHEMBL352992 IC50 = 480.0 nM 6.32
CHEMBL422564 IC50 = 670.0 nM 6.17
CHEMBL353070 IC50 = 980.0 nM 6.01
CHEMBL169797 IC50 = 1050.0 nM 5.98
CHEMBL352877 IC50 = 1200.0 nM 5.92