Assay Detail
Functional
CHEMBL624722
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In vitro cytotoxicity against A172 human tumor cell lines.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A 172 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro cytotoxicity of (RS)-20-desethyl-20-substituted camptothecin analogues
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.51 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166173 | — | — | 1 | 7.22 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.85 |
| CHEMBL169169 | — | — | 1 | 5.86 |
| CHEMBL354031 | — | — | 1 | 5.82 |
| CHEMBL301311 | — | — | 1 | 5.58 |
| CHEMBL167656 | — | — | 1 | 5.56 |
| CHEMBL354150 | — | — | 1 | 5.40 |
| CHEMBL166487 | — | — | 1 | 5.39 |
| CHEMBL353585 | — | — | 1 | 5.36 |
| CHEMBL432949 | — | — | 1 | 5.35 |
| CHEMBL168888 | — | — | 1 | 5.28 |
| CHEMBL352630 | — | — | 1 | 5.16 |
| CHEMBL355556 | — | — | 1 | 5.14 |
| CHEMBL355355 | — | — | 1 | 5.08 |
| CHEMBL167864 | — | — | 1 | 4.95 |
| CHEMBL355004 | — | — | 1 | 4.95 |
| CHEMBL352383 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166173 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL169169 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL354031 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL301311 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL167656 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL354150 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL166487 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL353585 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL432949 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL168888 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL352630 | — | IC50 | = | 6990.0 | nM | 5.16 |
| CHEMBL355556 | — | IC50 | = | 7190.0 | nM | 5.14 |
| CHEMBL355355 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL167864 | — | IC50 | = | 11230.0 | nM | 4.95 |
| CHEMBL355004 | — | IC50 | = | 11140.0 | nM | 4.95 |
| CHEMBL352383 | — | IC50 | = | 17590.0 | nM | 4.75 |