Assay Detail
Functional
CHEMBL624732
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for Growth inhibition of the human squamous cell carcinoma A253 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A253 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.08 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.89 |
| CHEMBL323565 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL323565 | — | EC50 | = | 540.0 | nM | 6.27 |