Assay Detail
Physicochemical
CHEMBL630127
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant (KD) of the compound
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Physicochemical |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.15 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505 | CHLORPHENIRAMINE | 4.0 | 1 | 8.43 |
| CHEMBL305660 | EBASTINE | 4.0 | 1 | 8.40 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 8.26 |
| CHEMBL553331 | — | — | 1 | 8.18 |
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505 | CHLORPHENIRAMINE | Kd | = | 3.7 | nM | 8.43 |
| CHEMBL305660 | EBASTINE | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL296419 | ASTEMIZOLE | Kd | = | 5.5 | nM | 8.26 |
| CHEMBL553331 | — | Kd | = | 6.6 | nM | 8.18 |
| CHEMBL17157 | TERFENADINE | Kd | = | 33.0 | nM | 7.48 |