Assay Detail
Binding
CHEMBL636450
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Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 70 | 5.84 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158507 | — | — | 1 | 7.72 |
| CHEMBL156863 | — | — | 1 | 7.68 |
| CHEMBL37243 | — | — | 1 | 7.47 |
| CHEMBL66337 | — | — | 1 | 7.43 |
| CHEMBL10873 | — | — | 1 | 7.43 |
| CHEMBL27041 | — | — | 1 | 7.40 |
| CHEMBL350469 | — | — | 1 | 7.33 |
| CHEMBL69701 | — | — | 1 | 7.22 |
| CHEMBL27047 | — | — | 1 | 7.22 |
| CHEMBL11348 | — | — | 1 | 7.21 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 7.20 |
| CHEMBL157836 | — | — | 1 | 7.10 |
| CHEMBL36740 | — | — | 1 | 6.90 |
| CHEMBL36867 | — | — | 1 | 6.86 |
| CHEMBL156178 | — | — | 1 | 6.73 |
| CHEMBL11332 | — | — | 1 | 6.54 |
| CHEMBL67110 | — | — | 1 | 6.51 |
| CHEMBL308660 | — | — | 1 | 6.51 |
| CHEMBL39986 | — | — | 1 | 6.44 |
| CHEMBL11635 | — | — | 1 | 6.41 |
| CHEMBL67949 | — | — | 1 | 6.39 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 6.38 |
| CHEMBL68278 | — | — | 1 | 6.38 |
| CHEMBL66899 | — | — | 1 | 6.34 |
| CHEMBL304455 | — | — | 1 | 6.29 |
| CHEMBL67415 | — | — | 1 | 6.26 |
| CHEMBL67228 | — | — | 1 | 6.19 |
| CHEMBL307105 | — | — | 1 | 6.16 |
| CHEMBL302344 | — | — | 1 | 6.01 |
| CHEMBL157655 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158507 | — | Ki | = | 18.9 | nM | 7.72 |
| CHEMBL156863 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL37243 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL66337 | — | Ki | = | 36.7 | nM | 7.43 |
| CHEMBL10873 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL27041 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL350469 | — | Ki | = | 46.5 | nM | 7.33 |
| CHEMBL69701 | — | Ki | = | 59.5 | nM | 7.22 |
| CHEMBL27047 | — | Ki | = | 60.7 | nM | 7.22 |
| CHEMBL11348 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 63.8 | nM | 7.20 |
| CHEMBL157836 | — | Ki | = | 79.6 | nM | 7.10 |
| CHEMBL36740 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL36867 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL156178 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL11332 | — | Ki | = | 289.0 | nM | 6.54 |
| CHEMBL67110 | — | Ki | = | 311.0 | nM | 6.51 |
| CHEMBL308660 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL39986 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL11635 | — | Ki | = | 394.0 | nM | 6.41 |
| CHEMBL67949 | — | Ki | = | 408.0 | nM | 6.39 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL68278 | — | Ki | = | 421.0 | nM | 6.38 |
| CHEMBL66899 | — | Ki | = | 461.0 | nM | 6.34 |
| CHEMBL304455 | — | Ki | = | 511.0 | nM | 6.29 |
| CHEMBL67415 | — | Ki | = | 552.0 | nM | 6.26 |
| CHEMBL67228 | — | Ki | = | 646.0 | nM | 6.19 |
| CHEMBL307105 | — | Ki | = | 691.0 | nM | 6.16 |
| CHEMBL302344 | — | Ki | = | 965.0 | nM | 6.01 |
| CHEMBL157655 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL8488 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL286785 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL23903 | 7-CHLOROETHYLTHEOPHYLLINE | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL24107 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL66881 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL416013 | — | Ki | = | 1770.0 | nM | 5.75 |
| CHEMBL67313 | — | Ki | = | 2330.0 | nM | 5.63 |
| CHEMBL26406 | — | Ki | = | 3390.0 | nM | 5.47 |
| CHEMBL282038 | — | Ki | = | 4130.0 | nM | 5.38 |
| CHEMBL279898 | ENPROFYLLINE | Ki | = | 4730.0 | nM | 5.33 |
| CHEMBL26119 | — | Ki | = | 4890.0 | nM | 5.31 |
| CHEMBL628 | PENTOXIFYLLINE | Ki | = | 5180.0 | nM | 5.29 |
| CHEMBL273953 | — | Ki | = | 5530.0 | nM | 5.26 |
| CHEMBL67323 | — | Ki | = | 5620.0 | nM | 5.25 |
| CHEMBL20613 | — | Ki | = | 6240.0 | nM | 5.21 |
| CHEMBL290643 | — | Ki | = | 6530.0 | nM | 5.18 |
| CHEMBL416884 | — | Ki | = | 6940.0 | nM | 5.16 |
| CHEMBL68660 | — | Ki | = | 7580.0 | nM | 5.12 |
| CHEMBL308464 | — | Ki | = | 8710.0 | nM | 5.06 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 9070.0 | nM | 5.04 |