Assay Detail
Binding
CHEMBL636772
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Inhibition of ATP-ase activity in human colon tumor cell line (HCT116)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.67 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326082 | — | — | 1 | 5.39 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 4.87 |
| CHEMBL326651 | — | — | 1 | 4.84 |
| CHEMBL326564 | — | — | 1 | 4.82 |
| CHEMBL109822 | — | — | 1 | 4.77 |
| CHEMBL112953 | — | — | 1 | 4.52 |
| CHEMBL113194 | — | — | 1 | 4.39 |
| CHEMBL324951 | — | — | 1 | 4.27 |
| CHEMBL109612 | — | — | 1 | 4.12 |
| CHEMBL414883 | RADICICOL | — | 1 | - |
| CHEMBL112896 | — | — | 1 | - |
| CHEMBL113690 | — | — | 1 | - |
| CHEMBL112834 | — | — | 1 | - |
| CHEMBL326523 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326082 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL326651 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL326564 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL109822 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL112953 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL113194 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL324951 | — | IC50 | = | 53500.0 | nM | 4.27 |
| CHEMBL109612 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL414883 | RADICICOL | IC50 | < | 200.0 | nM | - |
| CHEMBL112896 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL113690 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL112834 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL326523 | — | IC50 | > | 200000.0 | nM | - |