Assay Detail
Functional
CHEMBL636873
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Inhibitory activity against AUC375 cell line
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UACC-375 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.71 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42100 | — | — | 1 | 8.11 |
| CHEMBL44207 | — | — | 1 | 7.96 |
| CHEMBL40716 | — | — | 1 | 7.82 |
| CHEMBL40865 | — | — | 1 | 7.72 |
| CHEMBL43809 | — | — | 1 | 7.70 |
| CHEMBL40586 | — | — | 1 | 7.54 |
| CHEMBL40515 | — | — | 1 | 7.51 |
| CHEMBL42490 | — | — | 1 | 7.41 |
| CHEMBL40776 | — | — | 1 | 7.38 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.32 |
| CHEMBL42571 | — | — | 1 | 7.32 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.15 |
| CHEMBL41450 | — | — | 1 | 7.03 |
| CHEMBL42201 | — | — | 1 | 7.01 |
| CHEMBL288699 | — | — | 1 | 7.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.95 |
| CHEMBL40359 | — | — | 1 | 6.85 |
| CHEMBL41290 | — | — | 1 | 6.83 |
| CHEMBL288217 | — | — | 1 | 6.81 |
| CHEMBL40924 | — | — | 1 | 6.65 |
| CHEMBL43931 | — | — | 1 | 6.38 |
| CHEMBL287719 | — | — | 1 | 6.33 |
| CHEMBL289120 | — | — | 1 | 6.31 |
| CHEMBL416242 | — | — | 1 | 6.29 |
| CHEMBL43763 | — | — | 1 | 6.28 |
| CHEMBL290060 | — | — | 1 | 6.14 |
| CHEMBL43920 | — | — | 1 | 6.08 |
| CHEMBL296224 | — | — | 1 | 5.86 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.69 |
| CHEMBL40314 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42100 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL44207 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL40716 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL40865 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL43809 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL40586 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL40515 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL42490 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL40776 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL42571 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL41450 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL42201 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL288699 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL40359 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL41290 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL288217 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL40924 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL43931 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL287719 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL289120 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL416242 | — | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL43763 | — | IC50 | = | 522.0 | nM | 6.28 |
| CHEMBL290060 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL43920 | — | IC50 | = | 839.0 | nM | 6.08 |
| CHEMBL296224 | — | IC50 | = | 1375.0 | nM | 5.86 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 2031.0 | nM | 5.69 |
| CHEMBL40314 | — | IC50 | = | 2159.0 | nM | 5.67 |
| CHEMBL40313 | — | IC50 | = | 3133.0 | nM | 5.50 |
| CHEMBL40568 | — | IC50 | = | 5333.0 | nM | 5.27 |
| CHEMBL41561 | — | IC50 | = | 6132.0 | nM | 5.21 |
| CHEMBL289729 | — | IC50 | = | 7290.0 | nM | 5.14 |