Assay Detail
Functional
CHEMBL636929
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Tested for cytotoxicity against Doxo resistant A2780 type ADR5000 cell line expressing MDR-1 (++) gene
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ADR5000 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, hydrolytic activation and cytotoxicity of etoposide prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.54 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3215425 | — | — | 1 | 5.19 |
| CHEMBL3215424 | — | — | 1 | 4.42 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3215425 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3215424 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 100000.0 | nM | 4.00 |