Assay Detail
Functional
CHEMBL636948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for the inhibition of human gastrointestinal adenocarcinoma cells in vitro by HuTu 80 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.52 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305177 | — | — | 1 | 8.46 |
| CHEMBL304397 | — | — | 1 | 8.15 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.05 |
| CHEMBL305253 | — | — | 1 | 7.82 |
| CHEMBL303654 | — | — | 1 | 6.92 |
| CHEMBL423123 | — | — | 1 | 6.82 |
| CHEMBL69713 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305177 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL304397 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL305253 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL303654 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL423123 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL69713 | — | IC50 | = | 360.0 | nM | 6.44 |