Assay Detail
Binding
CHEMBL637384
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In vitro inhibitory activity against acetylcholinesterase (AChE) in Electrophorus electricus
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.48 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.80 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 4.46 |
| CHEMBL75699 | — | — | 1 | 4.17 |
| CHEMBL75644 | — | — | 1 | - |
| CHEMBL310961 | — | — | 1 | - |
| CHEMBL80382 | — | — | 1 | - |
| CHEMBL80224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL75699 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL75644 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL310961 | — | IC50 | = | 9900000.0 | nM | - |
| CHEMBL80382 | — | IC50 | = | 580000.0 | nM | - |
| CHEMBL80224 | — | IC50 | = | 650000.0 | nM | - |