Assay Detail
Binding
CHEMBL638563
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Binding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.66 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158507 | — | — | 1 | 7.72 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 6.38 |
| CHEMBL8488 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158507 | — | Ki | = | 18.9 | nM | 7.72 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL8488 | — | Ki | = | 1330.0 | nM | 5.88 |