Assay Detail
Binding
CHEMBL638564
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Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.56 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8732 | — | — | 1 | 8.27 |
| CHEMBL8495 | — | — | 1 | 7.89 |
| CHEMBL8810 | — | — | 1 | 7.64 |
| CHEMBL412854 | — | — | 1 | 7.58 |
| CHEMBL266099 | — | — | 1 | 7.37 |
| CHEMBL418333 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8732 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL8495 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL8810 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL412854 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL266099 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL418333 | — | Ki | = | 250.0 | nM | 6.60 |