Assay Detail
Functional
CHEMBL639911
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Evaluated for the inhibition of human gastrointestinal adenocarcinoma cells in vitro by SW480 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.47 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305177 | — | — | 1 | 8.43 |
| CHEMBL304397 | — | — | 1 | 8.30 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.82 |
| CHEMBL305253 | — | — | 1 | 7.58 |
| CHEMBL303654 | — | — | 1 | 7.08 |
| CHEMBL423123 | — | — | 1 | 6.70 |
| CHEMBL69713 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305177 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL304397 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL305253 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL303654 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL423123 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL69713 | — | IC50 | = | 420.0 | nM | 6.38 |