Assay Detail
Functional
CHEMBL640032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 7.63 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414185 | — | — | 1 | 9.10 |
| CHEMBL97859 | — | — | 1 | 8.90 |
| CHEMBL95523 | — | — | 1 | 8.60 |
| CHEMBL319553 | — | — | 1 | 8.50 |
| CHEMBL318544 | — | — | 1 | 8.10 |
| CHEMBL98243 | — | — | 1 | 8.10 |
| CHEMBL99559 | — | — | 1 | 8.00 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 7.90 |
| CHEMBL329928 | — | — | 1 | 7.90 |
| CHEMBL99362 | — | — | 1 | 7.90 |
| CHEMBL97044 | — | — | 1 | 7.80 |
| CHEMBL100383 | — | — | 1 | 7.70 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 7.70 |
| CHEMBL100198 | — | — | 1 | 7.70 |
| CHEMBL320419 | — | — | 1 | 7.70 |
| CHEMBL421011 | — | — | 1 | 7.50 |
| CHEMBL329272 | — | — | 1 | 7.40 |
| CHEMBL450018 | — | — | 1 | 7.30 |
| CHEMBL98016 | — | — | 1 | 7.30 |
| CHEMBL761 | NAPHAZOLINE | 4.0 | 1 | 7.20 |
| CHEMBL95565 | — | — | 1 | 7.10 |
| CHEMBL98769 | — | — | 1 | 7.00 |
| CHEMBL95245 | — | — | 1 | 6.90 |
| CHEMBL95333 | — | — | 1 | 6.40 |
| CHEMBL95398 | — | — | 1 | 6.30 |
| CHEMBL432192 | — | — | 1 | 6.30 |
| CHEMBL320910 | — | — | 1 | - |
| CHEMBL98921 | — | — | 1 | - |
| CHEMBL96988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414185 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL97859 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL95523 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL319553 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL318544 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL98243 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL99559 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL13852 | CIRAZOLINE | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL329928 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL99362 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL97044 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL100383 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL762 | OXYMETAZOLINE | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL100198 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL320419 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL421011 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL329272 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL450018 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL98016 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL761 | NAPHAZOLINE | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL95565 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL98769 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL95245 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL95333 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL95398 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL432192 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL320910 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL98921 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL96988 | — | EC50 | < | 5011.87 | nM | - |