Assay Detail
Binding
CHEMBL640171
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Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.54 | 9.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.65 |
| CHEMBL25554 | — | — | 1 | 9.29 |
| CHEMBL144286 | — | — | 1 | 7.80 |
| CHEMBL143026 | — | — | 1 | 7.72 |
| CHEMBL145785 | — | — | 1 | 7.61 |
| CHEMBL2112853 | — | — | 1 | 7.60 |
| CHEMBL143558 | — | — | 1 | 6.70 |
| CHEMBL423018 | — | — | 1 | 6.70 |
| CHEMBL144779 | — | — | 1 | 6.41 |
| CHEMBL145793 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Ki | = | 0.2239 | nM | 9.65 |
| CHEMBL25554 | — | Ki | = | 0.5129 | nM | 9.29 |
| CHEMBL144286 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL143026 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL145785 | — | Ki | = | 24.55 | nM | 7.61 |
| CHEMBL2112853 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL143558 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL423018 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL144779 | — | Ki | = | 389.05 | nM | 6.41 |
| CHEMBL145793 | — | Ki | = | 1148.15 | nM | 5.94 |