Assay Detail
Binding
CHEMBL640476
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Inhibition of human alphaIIb-beta3 integrin in platelet aggregation assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Molecular model of the alpha(IIb)beta(3) integrin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.24 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59562 | — | — | 1 | 8.00 |
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | 7.82 |
| CHEMBL326492 | — | — | 1 | 7.80 |
| CHEMBL359331 | — | — | 1 | 6.80 |
| CHEMBL123374 | — | — | 1 | 5.80 |
| CHEMBL150678 | — | — | 1 | - |
| CHEMBL86992 | — | — | 1 | - |
| CHEMBL313763 | — | — | 1 | - |
| CHEMBL300008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59562 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL916 | TIROFIBAN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL326492 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL359331 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL123374 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL150678 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL86992 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL313763 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL300008 | — | IC50 | > | 10000.0 | nM | - |