Assay Detail
Binding
CHEMBL640501
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Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.44 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 7.79 |
| CHEMBL72768 | — | — | 1 | 7.74 |
| CHEMBL70751 | — | — | 1 | 7.38 |
| CHEMBL540542 | — | — | 1 | 7.32 |
| CHEMBL306792 | — | — | 1 | 7.23 |
| CHEMBL72441 | — | — | 1 | 7.20 |
| CHEMBL540035 | — | — | 1 | 7.09 |
| CHEMBL553276 | — | — | 1 | 7.09 |
| CHEMBL70692 | — | — | 1 | 6.78 |
| CHEMBL72724 | — | — | 1 | 6.70 |
| CHEMBL70691 | — | — | 1 | 6.66 |
| CHEMBL70326 | — | — | 1 | 6.40 |
| CHEMBL70740 | — | — | 1 | 6.10 |
| CHEMBL74114 | — | — | 1 | 6.06 |
| CHEMBL542402 | — | — | 1 | 6.01 |
| CHEMBL70973 | — | — | 1 | 5.88 |
| CHEMBL74071 | — | — | 1 | 5.53 |
| CHEMBL71001 | — | — | 1 | 5.44 |
| CHEMBL71479 | — | — | 1 | 5.41 |
| CHEMBL74467 | — | — | 1 | 5.35 |
| CHEMBL70563 | — | — | 1 | 5.30 |
| CHEMBL544290 | — | — | 1 | 5.25 |
| CHEMBL419448 | — | — | 1 | - |
| CHEMBL70634 | — | — | 1 | - |
| CHEMBL302698 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL72768 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL70751 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL540542 | — | Ki | = | 47.86 | nM | 7.32 |
| CHEMBL306792 | — | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL72441 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL540035 | — | Ki | = | 81.28 | nM | 7.09 |
| CHEMBL553276 | — | Ki | = | 81.28 | nM | 7.09 |
| CHEMBL70692 | — | Ki | = | 165.96 | nM | 6.78 |
| CHEMBL72724 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL70691 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL70326 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL70740 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL74114 | — | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL542402 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL70973 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL74071 | — | Ki | = | 2951.21 | nM | 5.53 |
| CHEMBL71001 | — | Ki | = | 3630.78 | nM | 5.44 |
| CHEMBL71479 | — | Ki | = | 3890.45 | nM | 5.41 |
| CHEMBL74467 | — | Ki | = | 4466.84 | nM | 5.35 |
| CHEMBL70563 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL544290 | — | Ki | = | 5623.41 | nM | 5.25 |
| CHEMBL419448 | — | Ki | < | 7943.28 | nM | - |
| CHEMBL70634 | — | Ki | < | 7943.28 | nM | - |
| CHEMBL302698 | — | Ki | < | 7943.28 | nM | - |