Assay Detail
Binding
CHEMBL640604
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Displacement of [125I]ABA from adenosine A1 receptor of chick cerebellar membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.91 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45891 | — | — | 1 | 8.60 |
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 8.34 |
| CHEMBL1093910 | — | — | 1 | 8.19 |
| CHEMBL608800 | — | — | 1 | 8.07 |
| CHEMBL605042 | — | — | 1 | 8.07 |
| CHEMBL607777 | — | — | 1 | 7.99 |
| CHEMBL608798 | — | — | 1 | 7.89 |
| CHEMBL610427 | — | — | 1 | 7.88 |
| CHEMBL464859 | NECA | — | 1 | 7.77 |
| CHEMBL607951 | — | — | 1 | 7.72 |
| CHEMBL607666 | — | — | 1 | 7.60 |
| CHEMBL608217 | — | — | 1 | 7.38 |
| CHEMBL609086 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45891 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL262083 | N6-PHENYLADENOSINE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1093910 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL608800 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL605042 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL607777 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL608798 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL610427 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL464859 | NECA | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL607951 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL607666 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL608217 | — | IC50 | = | 42.1 | nM | 7.38 |
| CHEMBL609086 | — | IC50 | = | 45.1 | nM | 7.35 |