Assay Detail
Binding
CHEMBL640777
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Binding affinity for adenosine A1 receptor as inhibition of [125-I]-labeled aminobenzyl adenosine binding to bovine brain membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.44 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27041 | — | — | 1 | 7.77 |
| CHEMBL162558 | — | — | 1 | 6.02 |
| CHEMBL353115 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27041 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL162558 | — | Kd | = | 960.0 | nM | 6.02 |
| CHEMBL353115 | — | Kd | = | 2860.0 | nM | 5.54 |