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Assay Detail

CHEMBL640812

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Evaluated for norepinephrine as agonist.
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor alpha (CHEMBL2095203)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Arylethanolamines derived from salicylamide with alpha- and beta-adrenoceptor blocking activities. Preparation of labetalol, its enantiomers, and related salicylamides.
Clifton JE, Collins I, Hallett P, Hartley D, Lunts LH, Wicks PD.
J Med Chem (1982) 25 : 670 -679
PubMed 6124636 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 7.42 7.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1200323 LABETALOL HYDROCHLORIDE 4.0 1 7.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1200323 LABETALOL HYDROCHLORIDE Kd = 38.02 nM 7.42