Assay Detail
Binding
CHEMBL641044
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Binding affinity towards alpha 2 adrenergic receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conformationally defined adrenergic agents. 4. 1-(aminomethyl)phthalans: synthesis and pharmacological consequences of the phthalan ring oxygen atom.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.01 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31062 | — | — | 1 | 8.15 |
| CHEMBL433083 | — | — | 1 | 7.97 |
| CHEMBL31195 | — | — | 1 | 7.82 |
| CHEMBL52069 | — | — | 1 | 7.75 |
| CHEMBL281064 | — | — | 1 | 7.60 |
| CHEMBL299786 | — | — | 1 | 7.11 |
| CHEMBL31332 | — | — | 1 | 6.33 |
| CHEMBL442268 | — | — | 1 | 6.28 |
| CHEMBL297726 | — | — | 1 | 6.17 |
| CHEMBL53335 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31062 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL433083 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL31195 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL52069 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL281064 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL299786 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL31332 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL442268 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL297726 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL53335 | — | Ki | = | 13000.0 | nM | 4.89 |