Assay Detail
Functional
CHEMBL641171
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Dissociation constant for alpha IIb beta-3 integrin rested platelets
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.75 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78760 | — | — | 1 | 10.15 |
| CHEMBL78570 | — | — | 1 | 9.82 |
| CHEMBL40502 | — | — | 1 | 8.85 |
| CHEMBL79294 | — | — | 1 | 8.66 |
| CHEMBL32960 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78760 | — | Kd | = | 0.07 | nM | 10.15 |
| CHEMBL78570 | — | Kd | = | 0.15 | nM | 9.82 |
| CHEMBL40502 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL79294 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL32960 | — | Kd | = | 550.0 | nM | 6.26 |